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Buy Quality-Hydrocodone Powder Online. Zohydro ER and Hysingla ER are extended-release forms of hydrocodone that are used to treat severe pain around the clock. Extended-release hydrocodone is not intended for use for pain.

Hydrocodone may also be used for purposes not listed in this medication guide.

Hydrocodone is used to relieve moderate to severe pain. Contains an opioid analgesic (hydrocodone) and a non-opioid analgesic (acetaminophen). Hydrocodone works in the brain to change the way your body feels and responds to pain. Paracetamol can also lower the temperature.

Usual Adult Dose for Chronic Pain
The following dosing recommendations can only be considered suggested approaches. To what is actually a series of clinical decisions over time; each patient should be managed individually.

As First Opioid Analgesic and For Patients who are NOT Opioid Tolerant:
Extended-Release Capsules (Zohydro(R) ER): Initial dose: 10 mg orally every 12 hours
Extended-Release Tablets (Hysingla(R) ER): Initial dose: 20 mg orally every 24 hours

Comments:

Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression. Monitor patients closely for respiratory depression, especially during the first 24 to 72 hours.
An opioid tolerant patient is one who has been receiving for 1 week or longer at least: oral morphine 60 mg/day. Fentanyl transdermal patch 25 mcg per hour, oral oxycodone 30 mg/day, oral hydromorphone 8 mg/day. Oral oxymorphone 25 mg/day, or an equianalgesic dose of another opioid.

TITRATION AND MAINTENANCE:
Individually titrate to a dose that provides adequate analgesia and minimizes adverse reactions.
Dose adjustments to hydrocodone extended-release capsules should be made in 10 mg increments every 12 hours, every 3 to 7 days.
Dose adjustments to hydrocodone extended-release tablets should be made in 10 to 20 mg increments every 24 hours, every 3 to 5 days.
If unacceptable side effects occur, the dose may be reduced.
Breakthrough Pain: If the level of pain increases after dose stabilization. Attempt to identify the source before increasing dose; rescue medication with appropriate immediate-release analgesia may be helpful

DOSE CONVERSIONS: Dose conversions should be done carefully and with close monitoring due to large patient variability in regards to opioid analgesic response. Discontinue all other around the clock opioid drugs when initiating therapy with extended-release hydrocodone.

Hydrocodone Extended-Release (ER) CAPSULES:

The 50 mg capsules, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are reserved for opioid tolerant individuals.
Example: Sum the total daily dose of prior oral opioid; multiply that sum by the CF to obtain 24-hour oral hydrocodone requirement; divide 24-hour requirement by 2 (round down, if necessary ) and give 1 dose orally every 12 hours.
CONVERSION FROM TRANSDERMAL FENTANYL: Remove the transdermal fentanyl patch and 18 hours later initiate hydrocodone extended-release capsules at 10 mg every 12 hours for each 25 mcg/hr fentanyl transdermal patch; monitor closely as there is limited documented experience with this conversion.

Hydrocodone Extended-Release (ER) TABLETS:

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